IN- SITU NASAL GEL: MODERNISTIC ADVANCEMENT IN DRUG DELIVERY

In Situ Gel : An Innovative Approach for Safe and Sustained Nasal Drug Delivery

The human nose has the potential to be an alternative route for the systemic delivery of a wide range of therapeutic agents. The richly supplied vascular nature of the nasal mucosa and its high drug permeation makes it a potential route for the administration of many drugs including proteins, peptides and vaccines. Nasal route is most suitable for those drugs which cannot be administered orally...

Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery

Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC)  ratios were prepared and their stability was tested in P...

in situ gelling systems for drug delivery

Advancement and Tribulations in Ocular Drug Delivery

„Ocular drug delivery is one of the most interesting and challenging endeavours facing the pharmaceutical scientist...The anatomy, physiology and biochemistry of the eye render this organ exquisitely impervious to foreign substances...The challenge to the formulator is to outwit the protective barriers of the eye without causing permanent tissue damage...The ancient ophthalmic solutions, suspen...

nasal drug delivery in traditional persian medicine

discussion while this novel type of drug delivery is known as a suitable substitute for oral and parenteral administration, it was well accepted and extensively mentioned in persian medical and pharmaceutical manuscripts and other traditional systems of medicine as well. accordingly, medieval pharmaceutical standpoints on nasal dosage forms could still be an interesting subject of study. theref...